Inside Your Body: How Fat Cells Split And Burn Off Forever
By Kevin DiDonato MS, CSCS, CES
So here’s the story.
The other day we explained sick fat cells and how they can kill you slowly. Well, today, we are going to explain how fat stored in your cells is made into usable energy through a process called lipolysis.
You body needs fuel. Luckily for us, our muscles and liver provide a quick energy source in the form of stored sugar. However, in the absence of food or nutrients, our body uses our stored sugar. Luckily we have another storage system which has plenty of stored energy.
Fat cells are full of stored energy! When our bodies need energy, a process called lipolysis happens, which breaks down stored fat and releases them into the blood stream. Here is how the process works:
When we eat, food is used or stored as energy for future use. When we eat any type of fat or excess calories, these nutrients are processed and stored in adipocytes. Adipocytes are pockets in adipose tissue where fatty acids are stored for later. In order for us to utilize the stored energy, certain hormones have to be released. These hormones begin the process of splitting and releasing the stored energy.
The absence of food causes stress in the body. This stress increases Epinephrine and Norepinephrine. These hormones, which are secreted by the adrenal glands, stimulate fatty acids to mobilize from the cell getting them ready to be processed for energy.
Epinephrine binds to the surface of the cell, stimulating the production and release of adenylate cyclase. This increases the level of cAMP in the cell. The increased level of cAMP activates another hormone, PKA, stimulating the release of hormone-sensitive lipase (HSL). Here is where it gets fun!
Fat stored in the cell mobilizes and moves toward the surface. Once at the surface, hormone sensitive lipase splits the triacylglycerol, which is the stored fat form, cell at a certain point in the chain, hydrolyzing or splitting the fatty acid. The specific point in the chain, which is hydrolyzed, is part of the chemical backbone of the molecule. The fatty acid then moves into the bloodstream, transporting it to muscles or other cells. The fatty acid enters the cell and moves into the mitochondria, where the fat is burned for energy.
Two potent nutrients have shown the ability to aid in the process. We all know Capsaicin is hot! Capsimax® is an encapsulated bead(s) of Capsaicin, which allows the beadlets to enter the gut and move it into the intestines, with little breakdown. Capsimax® is most effective in the intestines. Once the beadlets hit the intestines, there is a slow release of Capsaicin into the bloodstream. This allows for Capsaicin to work effectively without the immense burn you would get from eating Capsaicin.
Capsaicin gives peppers their heat. Capsaicin can dramatically increase Epinephrine released by the body, therefore stimulating the fatty acid breakdown process. Result: more fat cells shredded and used for energy!
But wait….there’s more.
You might be thinking, "This is great, but how do more triacylglycerides get to the surface to be broken down?" Do I have the answer for you!
The other potent nutrient, Raz K®, works to help this process. Raz K® helps mobilize stored fat and move it to the surface of the cell. Once there, the fat cell is broken down, sending it on its way to other areas of the body. I will explain more about this in a minute.
Raspberry ketones are a natural phenolic compound found in raspberries. They can increase lipolysis, which is the breakdown of triacylglycerides into a more usable form. So, it comes as no surprise that Raz K® can also: release adiponectin, aid in fatty acid oxidation and, of course, lipolysis.
Research done by Park, determined rats who consumed a high-fat diet in combination with raspberry ketones, stunningly showed no additional increase in body weight or body fat. They also showed an increase in lipolysis, or the breakdown of fatty acids in the cell, shipping it to other areas for energy.
In a similar study, Morimoto et al. discovered rats fed a high-fat diet showed a build up of triglycerides in the liver. Those same rats were fed the same exact fat-enriched diet, this time with the addition of raspberry ketones. What they found will shock you!
By adding raspberry ketones, the rats fed the same high-fat diet did not increase their body weight. They also did not increase liver weight. They actually decreased their weight and the amount of fat in their livers, even though fat in the livers increased prior to the addition of raspberry ketones. Their final conclusion: raspberry ketones can prevent and improve obesity and fatty livers!
The reason why this formula is so effective is the use of Capsimax® and Raz K® together. The use of Capsimax® increases the secretion of Epinephrine and Norepinephrine, while Raz K® liberates the fat from the adipocytes, allowing them to be shredded and burned. This powerful combination increases fatty acid metabolism by providing more fuel for your fat burning machine to use for energy!
Prograde’s breakthrough Metabolism formula, contains these fat shredding, fat burning nutrients, which can help you lose weight and keep it off! The combination of Raz K® and the Capsimax® formula helps your body to support the mobilizing and burning of fat stores, making the fatty acids available to be obliterated in the muscle cells of our body!
Bloomer, R. Canale, R. Shastri, S. Suvarnapathki, S. Effect of oral intake of caspaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adult: a randomized, placebo, controlled, double-blind, cross-over study. Lipids In Health And Disease. 2010. Vol. 9(72).
Snitker, S. Fujishima, Y. Shen, H. Ou, S. Pi-Sunyer, X. Furuhata, Y. Sato, H. Takahashi, M. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr. 2009. Vol. 89; pp. 45-50.
Morimoto, C. Satoh, Y. Hara, M. Inoue, S. Tsujita, T. Okuda, H. Anti-obese actions of raspberry ketones. Life Sci. 2005. Vol. 77(2); pp. 194-204.
Park, KS. Raspberry ketones increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta Med. 2010. Vol. 76(15);pp. 1654-1648.
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