Free Presentation: How Krill Oil Can Reduce Inflammation

Watch this powerful presentation below to see exactly how Krill Oil can reduce inflammation in your body.

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Hi! This is Dr. Bryan Walsh, part of the research and development team with Prograde.



Today, we are going to show a short video on the anti-inflammatory effects of Krill oil and all the different compounds in it that can help you reduce inflammation.

Now, why should you be concerned with inflammation?



To be honest, inflammation is one of the most ubiquitous processes that are going on in peoples' bodies today, contributing to everything from cancer, to something as simple as fatigue, and everything else in between.



We all have some degree of inflammation going on and now, more than ever, we need potent anti-inflammatory substances to help block these inflammatory cascades that can ultimately lead us to a healthier, more asymptomatic life.



Now we’re going to talk about Krill oil and the number of different compounds in it, like omega-3 fatty acids, EPA and DHA, as well as some of the antioxidants and how they can actually help to lower your inflammation.



The first discussion we need to have has to do with fatty acids. There are things in nature called essential fatty acids, and they are called “essential” because your body cannot produce these - we need to get them from our diet.



One class of essential fatty acids is called omega-6. These come from things like corn oil, safflower oil, sunflower oil, and are also called linoleic acid. Now obviously with those types of oils, the omega-6 fats in our diets are generally very, very high.



We are abbreviating these pathways a bit, but linoleic acid coming from those particular oils is eventually converted down into something call DGLA, or dihomo-gamma-linolenic acid.  DGLA can then eventually be converted into an anti-inflammatory group of molecules, that we’ll just call the prostaglandin series one molecules.  So the green here are the anti-inflammatory pathways.



Also, there is another type of essential fats called omega-3 fatty acids. Now up here, omega-3 fatty acids are found in things like walnuts, flax oil, hemp oil or hemp seeds, and chia seeds. They have to go through a series of enzymatic conversions to eventually be converted into EPA, which can be converted also to DHA.  EPA can be converted into another anti-inflammatory group of compounds called prostaglandin three series, which are actually very, very anti-inflammatory.



So you can see just with this chart so far that EPA and DHA can be very potent in creating anti-inflammatory processes.



DGLA, however, can enzymatically be converted to something called arachidonic acid, and unfortunately arachidonic acid eventually creates a series of inflammatory products called prostaglandin series two. Now, what’s so inflammatory or anti-inflammatory about these?



Things like poor blood sugar regulation or control, can trigger the arachidonic cascade, which has been shown to increase inflammation, and to increase even your chances of getting cancer. So as much as possible, we want to block this arachidonic cascade. And, we will see in just a second how EPA and DHA can do that.

Here’s what happens is these are all fatty acids, DGLA, arachidonic acid, EPA, and DHA that are incorporated into the cell membrane. In the cell membrane, these fatty acids can be liberated, and when they are, or an enzyme acts on them and then they create these particular anti-inflammatory, or in the case of arachidonic acid, inflammatory prostaglandin pathways.



So what we want to try to do is decrease the inflammatory process, increase the anti-inflammatory processes, and here’s how Krill oil can help accomplish this.



EPA, specifically, has been shown to block this conversion of DGLA into arachidonic acid, just by itself.  So that’s a strong argument for EPA.

Also, when EPA is embedded in the cell membrane more than arachidonic acid, EPA has been shown to actually compete with the enzymes that turn arachidonic acid turn into the inflammatory prostaglandin series two pathway. So that’s another benefit of EPA.



Now on the other hand, when DHA is released from the cell membrane, it has its own anti-inflammatory compounds in it, which are actually very new in the medical research. DHA can make things like resolvins, neuroprotectins, and eicosanoids are very anti-inflammatory by themselves. But additionally, DHA has also been found to block the Prostaglandin Series Two pathway.

So you can see that simply by supplementing with EPA and DHA in the form of something like a highly bioavailable Krill oil, you can significantly reduce inflammation throughout your body.

But what else do the omega-3 fatty acids do?



In a cell, you have receptors that are called toll-like receptors. Now, there are a number of different types, but understand this: when the toll-like receptors receive input from outside of the cell, from bacteria, viruses, or certain chemicals, what they do is they send a message to the inside your cell to stimulate something called NF kappa B, or nuclear factor kappa beta.

Nuclear factor kappa beta is the subject of much research today because NF kappa B, is the amplifier for the inflammatory cascade, meaning that when NF kappa B is stimulated, it produces inflammation from a number of different pathways.

So you could chase those different pathways trying to stop inflammation, or you could simply block NF kappa beta from getting started in the first place.

And by the way, another thing that stimulates NF kappa B, or NF kappa beta, is arachidonic acid.

EPA has been shown to inhibit these toll-like receptors, which then inhibits the NF kappa beta activity and therefore decreases inflammation. This is very, very potent.

Here’s another thing it does. Here you have the nucleus of your cell.

Now arguably, the nucleus is the most important component of your cell. It is what contains your DNA, which is your book or life or, your genetic code. Anything that acts on the DNA is going to have genetic effects.

All of these other effects that we are talking about are more on the metabolic or chemical level. If omega-3 fatty acids act on your DNA, then it’s affecting your genes.

Now on the nucleus, you have what’s referred to as a PPAR receptors, or peroxisome proliferator-activated receptor. Some of these PPAR receptors have been found to be activated by EPA. In other words, EPA activates the PPAR receptor, which stimulates your nucleus, your DNA, and your genetic code, to actually improve things like fat metabolism and blood sugar control - both of those being very inflammatory.


Incidentally, the stimulation of the PPAR receptor on the nucleus is one of the mechanisms that EPA and DHA make may help with weight loss, because you are actually improving this cell’s ability to metabolize fatty acids, which is great - that’s what you want during a weight loss program.



Omega-3 fatty acids not only stimulates this cell, but the hundreds of trillions of cells within your body. The more cells that have these fatty acids, the easier it is to lose weight.

So obviously, EPA and DHA are highly anti-inflammatory in a number of different pathways.

We all have some degree of inflammation, maybe its joint pain, maybe its headaches, maybe you have blood sugar dysregulation, or honestly, maybe you actually feel relatively healthy.  You can pretty much guarantee that we all have these pathways going to some degree and therefore have some degree of inflammation. And again, inflammation has been shown to be associated with just about every chronic condition today.

Now there is one other component to discuss and is why Krill oil is actually more beneficial than fish oil for reducing inflammation. And that is a novel antioxidant called astaxanthin.
This antioxidant has the unique ability to actually incorporate itself into the cell membrane. This means that when astaxanthin is incorporated into the cell membrane, it can protect the cell from the outside, it can protect the cell from free radical damage and inflammation from the inside, and it can protect the cell from within the cell membrane itself.

It’s totally unique in its structure and its ability to offer anti-inflammatory and antioxidant effects on the body.



So for these reasons, and as more research comes out, probably even more, Krill oil in just two soft gels a day, is a phenomenal way of getting anti-inflammatory effects as well as antioxidant effects that currently no other supplement can offer in the same ways.